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Symbol
Name
ID

Cux2
cut-like homeobox 2
MGI:107321

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Cerebellar atrophy

Athetosis

EEG abnormality

Hypsarrhythmia

Reduced eye contact

Recurrent hand flapping

Intellectual disability

Dyskinesia

Dystonia

Gait disturbance

Epileptic encephalopathy

Developmental regression

Global developmental delay

Bilateral tonic-clonic seizure

Generalized non-motor (absence) seizure

Focal hemiclonic seizure

Generalized myoclonic seizure

Atonic seizure

Tonic seizure

Disease(s) Associated with CUX2

developmental and epileptic encephalopathy 67

Mouse Phenotypes

abnormal neuronal precursor proliferation

abnormal neural tube morphology

abnormal neural tube marginal layer morphology

abnormal neural tube ventricular layer morphology

increased brain size

abnormal cerebral cortex morphology

abnormal neocortex morphology

thickened cerebral cortex

abnormal embryonic/fetal subventricular zone morphology

increased neuron number

abnormal spinal cord interneuron morphology

abnormal ventral spinal root morphology

Availability

Mouse Genotype

Cux2^{Gt(OST440231)Lex}/Cux2^{Gt(OST440231)Lex}

Cux2^tm1.1Nieto/Cux2^tm1.1Nieto

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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